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Circulating angiotensin II and drinking behavior in rats.

C M Pawloski1, G D Fink

  • 1Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.

The American Journal of Physiology
|September 1, 1990
PubMed
Summary

Elevated angiotensin II (ANG II) levels in rats did not directly stimulate water intake or influence drinking responses to osmotic or hypotension challenges. These findings suggest ANG II is not a primary driver for thirst in these physiological conditions.

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Area of Science:

  • Physiology
  • Neuroendocrinology
  • Behavioral Neuroscience

Background:

  • Circulating angiotensin II (ANG II) is a key component of the renin-angiotensin system, involved in regulating blood pressure and fluid balance.
  • While ANG II is known to stimulate thirst in some contexts, its direct role in drinking behavior under various physiological conditions remains incompletely understood.

Purpose of the Study:

  • To investigate the effects of acute and chronic increases in circulating angiotensin II (ANG II) concentrations on water intake in rats.
  • To determine if ANG II influences drinking behavior elicited by osmotic stimuli or hypotension.

Main Methods:

  • Male Sprague-Dawley rats were instrumented for intravenous infusions and blood sampling.
  • ANG II was infused intravenously acutely (30 min-2 h) and chronically (3 days) at doses of 10-60 ng/min.

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  • Drinking responses were measured during ANG II infusion alone, during hypertonic saline infusion, and during nitroprusside-induced hypotension, with and without ANG II modulation.

    • Main Results:

    • Intravenous infusion of ANG II, at doses ranging from 10-60 ng/min, did not produce a statistically significant increase in water intake.
    • ANG II administration did not enhance drinking elicited by hypertonic saline infusion or alter the osmotic threshold for drinking.
    • Blocking ANG II formation with enalapril or concomitant ANG II infusion did not affect water intake during nitroprusside-induced hypotension.

    Conclusions:

    • The range of circulating angiotensin II concentrations typically found in physiological conditions in rats does not directly stimulate drinking.
    • Angiotensin II does not appear to play a significant role in mediating drinking behavior in response to osmotic challenges or hypotension in rats.