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Updated: May 8, 2026

Dissecting Innate Immune Signaling in Viral Evasion of Cytokine Production
Published on: March 2, 2014
HIV and innate immunity - a genomics perspective
Antonio Rausell1, Paul J McLaren, Amalio Telenti
1Institute of Microbiology, University Hospital of Lausanne and University of Lausanne Switzerland ; Swiss Institute of Bioinformatics, Lausanne Switzerland.
Abstract:
Innate immunity is a theme of increasing interest for HIV research. However, the term is overstretched to cover biological barriers, cellular systems, soluble factors, signaling pathways, and effectors and is inconsistently applied. A clearer semantic classification of the components of innate immunity is needed, which will have direct relevance to the interpretation of human genome variation. Here, we discuss genomic approaches that can assist in re-defining the perimeter of innate immunity. We place particular emphasis on the characteristics of effectors of the intracellular defense against HIV and other pathogens.
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