[New Helicobacters other than H. pylori].
Kenji Yokota1, Masahide Kita, Hiroyuki Okada
1Graduate School of Health Science, Okayama University.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 24, 2013
Summary
Non-H. pylori Helicobacter species (NHPH) are increasingly recognized as potential human pathogens. Some NHPH strains, including enterohepatic Helicobacter species, are linked to various human diseases, suggesting future clinical significance.
Area of Science:
- Microbiology
- Infectious Diseases
- Gastroenterology
Background:
- Over 30 non-H. pylori Helicobacter species (NHPH) have been identified since H. pylori discovery.
- NHPH are classified into gastric and enterohepatic Helicobacter species (EHS).
- Gastric NHPH exhibit distinct morphology and potential zoonotic transmission causing gastritis.
Purpose of the Study:
- To review the classification and clinical relevance of non-H. pylori Helicobacter species.
- To highlight the association of EHS, such as H. hepaticus and H. cinaedi, with human diseases.
Main Methods:
- Literature review and classification of identified NHPH species.
- Analysis of reported human infections and associated pathologies linked to NHPH.
Main Results:
- Gastric NHPH can be differentiated from H. pylori by light microscopy.
- Enterohepatic Helicobacter species (EHS), including H. hepaticus and H. cinaedi, have been detected in human infections.
- H. hepaticus is implicated in hepatobiliary diseases, while H. cinaedi is associated with atrial arrhythmias and atherosclerosis.
Conclusions:
- NHPH represent a growing group of bacteria with significant clinical implications.
- Enterohepatic Helicobacter species are increasingly recognized as human pathogens.
- Many NHPH species are likely to be identified as human pathogens in the future.
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