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Updated: May 8, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
[Helicobacter pylori eradication for gastric MALT lymphoma]
Shotaro Nakamura1, Takayuki Matsumoto, Takanari Kitazono
1Center for Advanced Medical Innovation, Kyushu University.
Abstract:
Clinical features and efficacy of Helicobacter pylori (H. pylori) eradication for patients with gastric MALT lymphoma are reviewed. Gastric MALT lymphoma comprises 1-5% of all gastric malignancies, while 40-50% of primary gastric lymphomas. In approximately 90% of cases, H. pylori infection plays the causative role in the pathogenesis, and H. pylori eradication is nowadays the first-line treatment for this disease, which leads to complete disease remission in 60-90% of cases. Predictive factors for resistance to eradication therapy include absence of H. pylori infection, deep invasion in the gastric wall, t(11:18)/API2-MALT1, and etc. Recently a large-scale Japanese multicenter study demonstrated that the long-term clinical outcome of gastric MALT lymphoma after H. pylori eradication is excellent.
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