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Updated: May 8, 2026

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

A Point-of-Care Method with Integrated Decision Support Tool to Estimate Anemia at Population Level

Published on: January 19, 2024

[Iron-deficiency anemia].

Mutsuko Konno¹, Nariaki Toita, Shin-ichi Yokota

¹Department of Pediatrics, Sapporo Kosei General Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine

|August 24, 2013

Summary

Helicobacter pylori strains from iron-deficiency anemia patients exhibit enhanced iron uptake due to a specific Nap A protein variant. This finding deepens our understanding of IDA pathogenesis and H. pylori interactions.

Area of Science:

Microbiology
Gastroenterology
Hematology

Background:

A significant association between iron-deficiency anemia (IDA) and Helicobacter pylori infection has been observed.
Previous research indicated that H. pylori strains from IDA patients possess heightened iron uptake capabilities and iron-dependent proliferation.
The genetic basis for these observed differences in H. pylori strains related to IDA remains to be fully elucidated.

Purpose of the Study:

To investigate the genetic differences in key iron-related genes (nap A, fur, and feo B) between H. pylori strains from IDA and non-IDA patients.
To determine the specific role of neutrophil-activating protein A (Nap A) variants in iron acquisition by H. pylori.
To correlate the presence of specific Nap A types with iron uptake efficiency in H. pylori strains.

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Main Methods:

Nucleotide sequencing of nap A, fur, and feo B genes from H. pylori strains isolated from 24 IDA patients and 25 non-IDA patients.
Analysis of the frequency of different Nap A variants, specifically Thr70-type and Ser70-type, in the studied H. pylori strains.
Measurement and comparison of Fe3+ and Fe2+ uptake levels in H. pylori strains expressing different Nap A variants.

Main Results:

The frequency of the Thr70-type Nap A variant was significantly higher in H. pylori strains isolated from IDA patients compared to non-IDA patients.
H. pylori strains possessing the Thr70-type Nap A exhibited significantly greater Fe3+ and Fe2+ uptake compared to strains with the Ser70-type Nap A.
The Ser70-type Nap A variant, found in standard strains, showed lower iron uptake levels.

Conclusions:

The Thr70-type Nap A variant is a key factor contributing to the enhanced iron uptake observed in H. pylori strains associated with iron-deficiency anemia.
This specific Nap A variant may play a crucial role in the pathogenesis of IDA by facilitating greater iron acquisition by H. pylori.
Further research into the mechanisms of iron uptake and the role of Nap A in H. pylori-IDA interactions is warranted.