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Flow Cytometric Analysis of Particle-bound Bet v 1 Allergen in PM10
Published on: November 19, 2016
Soy aeroallergens in thoracic fraction particles (PM10)
S Gómez-Ollés1, M D Untoria, J R Villalbi
1Servicio de Neumología, Hospital Universitario Vall d'Hebron, Barcelona, Spain. susana.go@vhir.org
Journal of Investigational Allergology & Clinical Immunology
|August 24, 2013
Summary
Airborne soybean allergens in fine particulate matter (PM10) vary daily. Total suspended particulate (TSP) filters are not reliable indicators of PM10 soy allergen content due to significant daily fluctuations.
Area of Science:
- Environmental Science
- Allergy and Immunology
- Aerobiology
Background:
- Aerodynamic particle diameter influences respiratory system penetration.
- Soybean aeroallergens pose a health risk, necessitating exposure control.
Purpose of the Study:
- Assess allergen content in fine particulate matter (<10 µm) to improve soybean aeroallergen exposure control.
- Investigate the relationship between soy aeroallergens in PM10 and total suspended particulates (TSP).
Main Methods:
- Collected 98 parallel pairs of PM10 and TSP filters.
- Analyzed filters for soy aeroallergens using inhibition enzyme-linked immunosorbent assay.
Main Results:
- Median soy aeroallergen levels were 6 U/m³ for PM10 and 22.5 U/m³ for TSP.
- A strong correlation existed between soy aeroallergen content in PM10 and TSP filters.
- Soy aeroallergens in PM10 constituted a median of 28.6% of TSP content, with wide daily variations.
Conclusions:
- TSP filters are not a reliable surrogate for PM10 soy allergen content due to high daily variability.
- Further clinical research is needed to understand the health impacts of soy allergens in different particle size fractions (PM10 vs. TSP).
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