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Updated: May 8, 2026
06:38
Determination of Reproductive Competence by Confirming Pubertal Onset and Performing a Fertility Assay in Mice and Rats
Published on: October 13, 2018
Menarche, puberty and psychiatric disorders
Esra Yazici1, Fusun Sevimli Bursalioglu, Nazan Aydin
1Department of Psychiatry, Kocaeli Derince Training and Research Hospital , Kocaeli , Turkey .
Summary
Early puberty and adolescent mental health are linked to psychiatric disorders. Family history and early menarche correlate with conditions like schizophrenia and bipolar disorder.
Area of Science:
- Psychiatry
- Adolescent Health
- Mental Health Research
Background:
- Puberty and adolescence are critical developmental periods significantly influencing mental health outcomes, especially in women.
- Understanding the interplay between pubertal milestones, adolescent psychiatric issues, and familial psychiatric history is crucial for early intervention and treatment.
Purpose of the Study:
- To investigate the relationship between the age of menarche, psychiatric complaints during adolescence, and family history of psychiatric disorders.
- To explore these associations across different psychiatric diagnoses, including schizophrenia, bipolar affective disorder, and depressive disorder.
Main Methods:
- The study included 61 schizophrenia patients, 35 bipolar affective disorder patients, 40 depressive disorder patients, and 60 healthy controls.
- All participants underwent evaluation using the Structured Clinical Interview for DSM-IV (SCID-I) and a purpose-designed questionnaire.
Main Results:
- Bipolar affective disorder showed a significant association with menarche.
- Early onset of psychiatric illness in schizophrenia and bipolar disorder groups was linked to psychiatric problems during adolescence.
- A family history of psychiatric illness correlated with psychological issues during puberty in the schizophrenia group.
Conclusions:
- The study highlights the critical role of the puberty and adolescence period in the development of psychiatric illness.
- An integrative clinical approach is recommended, considering hormonal effects of menarche, social impacts of adolescent psychiatric complaints, and the genetic and psychosocial burden of family history.
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