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Kocuria kristinae: a true pathogen in pediatric patients
Hsin-Mao Chen1, Hsin Chi2, Nan-Chang Chiu2
1Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan; Department of Pediatrics, Zhongxing Branch, Taipei City Hospital, Taipei, Taiwan.
Summary
Kocuria kristinae, a rare pathogen, can cause healthcare-associated infections in premature infants and immunocompromised children, particularly those with central venous catheters. Prompt diagnosis and treatment are crucial for susceptible pediatric patients.
Area of Science:
- Medical Microbiology
- Infectious Diseases
- Pediatrics
Background:
- Kocuria kristinae is a Gram-positive bacterium infrequently identified as a human pathogen.
- While recognized as a potential pathogen in immunocompromised adults, its role in pediatric infections remains underreported.
- This study addresses the limited data on Kocuria kristinae infections in pediatric populations.
Purpose of the Study:
- To investigate the occurrence and characteristics of Kocuria kristinae bloodstream infections in pediatric patients.
- To identify risk factors and clinical presentations associated with Kocuria kristinae infections in a Taiwanese tertiary-care hospital.
Main Methods:
- Retrospective analysis of clinical data from pediatric patients with Kocuria kristinae isolated from blood cultures between January 2008 and May 2012.
- Inclusion criteria focused on patients with positive blood cultures for Kocuria kristinae.
Main Results:
- Seven out of 12 patients with Kocuria kristinae in blood cultures were confirmed to have bloodstream infections.
- Infections predominantly occurred in premature infants (six) and one child with acute leukemia, all with healthcare-associated origins.
- Central venous catheters were present in all infected premature infants, and Kocuria kristinae was also isolated from catheter tips in some cases.
Conclusions:
- Kocuria kristinae is a significant pathogen capable of causing bloodstream infections in vulnerable pediatric patients, especially neonates and immunocompromised children.
- Long-term use of intravenous catheters is a key risk factor for Kocuria kristinae infections in this population.
- The findings underscore the need to consider Kocuria kristinae as a true pathogen and ensure appropriate management in susceptible pediatric cases.
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