Related Experiment Video
Updated: May 8, 2026

An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
Published on: July 22, 2011
Genome Sequence of Salmonella enterica Serovar Typhi Oral Vaccine Strain Ty21a
Deqi Xu1, John O Cisar, Frédéric Poly
1Laboratory of Enteric and Sexually Transmitted Diseases, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Bethesda, Maryland, USA.
Abstract:
Attenuated Salmonella enterica serovar Typhi strain Ty21a is an important vaccine for controlling typhoid fever and serves as an oral vector for delivering heterologous antigens. The key attenuating features of this randomly mutated strain remain in question. Genome sequencing has revealed 679 single nucleotide polymorphisms (SNPs), and will help define alterations contributing to Ty21a safety and immunogenicity.
Related Concept Videos
Evolution of Microbial Genome
Bacterial Gastroenteritis
Cholera
DNA Bacteriophages
