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Related Experiment Video

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Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Isolation and Culture of Primary Synovial Macrophages and Fibroblasts from Murine Arthritis Tissue

Published on: February 24, 2023

Inflammatory pathways in spondyloarthritis.

Hulda S Hreggvidsdottir¹, Troy Noordenbos, Dominique L Baeten

¹Department of Clinical Immunology and Rheumatology, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; Tytgat Institute for Liver and Intestinal Research, Academic Medical Center/University of Amsterdam, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.

Molecular Immunology

|August 24, 2013

Summary

Spondyloarthritis involves new bone growth. Different forms of TNF and the IL-23/IL-17 pathway contribute to this, offering new therapeutic targets for ankylosing spondylitis.

Keywords:

Ankylosing spondylitis Cytokines IL-23 Spondyloarthritis TNF

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Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Du-Moxibustion in a Mouse Model of Ankylosing Spondylitis

Published on: October 27, 2023

Area of Science:

Immunology
Rheumatology
Genetics

Background:

Spondyloarthritis (SpA) is a common inflammatory arthritis characterized by new bone formation.
Cytokine pathways, including TNF and IL-23/IL-17, are implicated in SpA pathogenesis, particularly ankylosing spondylitis (AS).

Purpose of the Study:

To review recent genetic associations and experimental data on cytokine pathways in SpA.
To discuss the role of these pathways in SpA pathophysiology and new bone formation.

Main Methods:

Review of genetic association studies.
Analysis of experimental data from animal models.
Examination of human in vivo data.

Main Results:

Transmembrane TNF overexpression models show axial and peripheral new bone formation, distinct from soluble TNF.
The IL-23/IL-17 axis is increasingly recognized, with genetic links and therapeutic potential in AS.
Multiple cytokine pathways (TNF, IL-1, IL-6, IL-23/IL-17) are involved in SpA.

Conclusions:

Distinct roles for soluble and transmembrane TNF in SpA bone formation.
The IL-23/IL-17 pathway is a significant factor in AS development and progression.
Understanding these cytokine pathways is crucial for targeting SpA pathophysiology and new bone formation.