[Bilateral 23Na MR imaging of the breast and quantification of sodium concentration]
Meike Danisch1, Raffi Kalayciyan1, Friedrich Wetterling2
1Computerunterstützte Klinische Medizin, Medizinische Fakultät Mannheim, Universität Heidelberg, Theodor-Kutzer-Ufer 1-3, D-68167 Mannheim, Germany.
Abstract:
A novel setup for (23)Na MRI, which allows bilateral imaging of the breast, is presented. For this purpose a figure-eight receive-only (23)Na surface coil was developed. For our experiments on three samples with NaCl solutions of different sodium concentrations and two female subjects we used an asymmetric birdcage coil in transmit mode and the developed surface coil for receiving the signal at 3T. Imaging of the samples showed the applicability of the employed normalization method for measuring the distribution of sodium concentration. In a sample of concentration [Na(+)]=51mM we achieved SNR=70 at a nominal isotropic resolution of 2,5mm (TR=66ms, TE=0,6ms, TA=20min). Furthermore we showed that by means of this setup it is possible to quantify the sodium concentration in breast tissue (TSC) of a female subject with an accuracy of 23% (TR=150ms, TE=0,5ms, TA=45min).
