Related Experiment Video
Updated: May 8, 2026
08:02
Fecal Glucocorticoid Analysis: Non-invasive Adrenal Monitoring in Equids
Published on: April 25, 2016
Equine's Cushing's Disease: A Clinical Update.
1University of North Carolina, School of Pharmacy, Chapel Hill, North Carolina.
International Journal of Pharmaceutical Compounding
|August 24, 2013
Summary
This study reviews treatments for equine Cushing's disease. It discusses pharmacological options and disease pathophysiology, with stability studies of pergolide oral suspensions pending.
Area of Science:
- Veterinary Pharmacology
- Equine Endocrinology
Background:
- Equine Cushing's disease, also known as pituitary pars intermedia dysfunction (PPID), is a common endocrine disorder in horses.
- Understanding the pathophysiology is crucial for developing effective treatments.
Purpose of the Study:
- To provide insight into the pathophysiology of equine Cushing's disease.
- To summarize current literature on clinical treatments for equine Cushing's disease.
- To discuss available pharmacological options for treating equine Cushing's disease.
Main Methods:
- Literature search on clinical treatments for equine Cushing's.
- Review of pharmacological options for equine Cushing's disease.
Main Results:
- The literature search identified various clinical treatment strategies for equine Cushing's.
- Pharmacological approaches are discussed in detail.
- Stability studies of pergolide oral suspensions are ongoing but not yet available.
Conclusions:
- A comprehensive understanding of equine Cushing's pathophysiology is essential.
- Multiple pharmacological options exist for managing equine Cushing's.
- Further research, including stability studies of pergolide, is needed to optimize treatment.
More Related Videos
Related Concept Videos
01:19Cushing Syndrome II: Pathophysiology
Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
01:26Cushing Syndrome I: Introduction
Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...
01:27Adrenal Gland Disorders
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
01:26Heart Failure III: Clinical Manifestations
Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
01:29Cardiomyopathy III: Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
01:30Pulmonary Hypertension: Classification and Pathogenesis
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...