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mRNA expression pattern of retinoic acid and retinoid X nuclear receptor subtypes in human thyroid papillary

Dana Macejová1, Stefan Galbavý, Ján Podoba

  • 1Institute of Experimental Endocrinology, Slovak Academy of Sciences, 833 06 Bratislava, Slovak Republic.

Oncology Reports
|August 24, 2013
PubMed

Insights

Retinoid signaling pathways, including retinoic acid receptor (RAR) and retinoid X receptor (RXR) subtypes, show altered expression in papillary thyroid carcinoma (PTC). These changes, particularly in RXRγ, RARα, and RARγ, may aid in differential diagnosis.

Area of Science:

  • Molecular Biology
  • Oncology
  • Endocrinology

Background:

  • Retinoids are known for their potential in inhibiting tumor growth.
  • Understanding the expression patterns of nuclear receptors and deiodinase is crucial for thyroid cancer research.

Purpose of the Study:

  • To investigate the expression of retinoic acid nuclear receptor (RAR) and retinoid X receptor (RXR) subtypes and iodothyronine 5'-deiodinase, type I (hDIO1) in papillary thyroid carcinoma (PTC).
  • To compare these expression patterns between tumor and non-neoplastic thyroid tissues.

Main Methods:

  • Semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) was used to examine mRNA expression.
  • 26 patients with PTC were analyzed, comparing tumor tissue with corresponding non-neoplastic tissue.

Main Results:

  • Papillary thyroid carcinoma (PTC) tissues showed increased expression of RXRγ, RARα, and RARγ compared to non-neoplastic tissues.
  • RARβ was significantly reduced in the classic variant (CV) subgroup.
  • hDIO1 mRNA expression was significantly lower in tumor tissues, especially in cases with negative lymph node metastasis.

Conclusions:

  • Altered expression of RAR and RXR subtypes in PTC may contribute to tumor progression.
  • These molecular differences could potentially be exploited in the clinical oncology setting for differential diagnosis of thyroid neoplasms.

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