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Related Concept Videos

Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
Replicative Cell Senescence02:15

Replicative Cell Senescence

Replicative cell senescence is a property of cells that allows them to divide a finite number of times throughout the organism's lifespan while preventing excessive proliferation. Replicative senescence is associated with the gradual loss of the telomere — short, repetitive DNA sequences found at the end of the chromosomes. Telomeres are bound by a group of proteins to form a protective cap on the ends of chromosomes. Embryonic stem cells express telomerase — an enzyme that adds the telomeric...
The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Cellular Adaptation I: Introduction and Atrophy01:23

Cellular Adaptation I: Introduction and Atrophy

Cells can adapt to environmental changes to maintain function and avoid injury, a process called cellular adaptation. Adapted cells exist in a reversible intermediate state with changes in size, number, phenotype, metabolism, or function. These responses help cells meet altered physiological or pathological demands; for example, enlargement of breast and uterine tissues during pregnancy. Early adaptations may enhance function, but persistent stress eventually causes tissue damage.Types of...
Unrenewable Cells00:50

Unrenewable Cells

In humans, the photoreceptor cells of the eye and sensory hair cells of the ear lack stem cells. These cells are thus unrenewable and cannot be replaced when they are damaged or destroyed.
Photoreceptors
The retina is composed of several layers and contains specialized cells called photoreceptors. The photoreceptors (rods and cones) change their membrane potential when stimulated by light energy. There are two types of photoreceptors—rods and cones—which differ in the shape of their outer...

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Updated: May 8, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
08:18

Induction and Validation of Cellular Senescence in Primary Human Cells

Published on: June 20, 2018

Senescence at a glance.

Jeff S Pawlikowski1, Peter D Adams, David M Nelson

  • 1Institute of Cancer Sciences, Cancer Research UK Beatson Laboratories, University of Glasgow, Glasgow G61 1BD, UK.

Journal of Cell Science
|August 24, 2013
PubMed
Summary
This summary is machine-generated.

Cellular senescence, a state of stable cell cycle arrest, influences diverse functions like aging and wound healing. This research explores senescence

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Last Updated: May 8, 2026

Induction and Validation of Cellular Senescence in Primary Human Cells
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A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
13:59

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Area of Science:

  • Cellular and Molecular Biology
  • Gerontology
  • Oncology

Background:

  • Cellular senescence is a stable cell cycle arrest.
  • It involves significant cellular remodeling and changes in the secretory pathway.
  • Senescence has diverse roles in physiological and pathological processes.

Purpose of the Study:

  • To summarize the initiators and pathways of cellular senescence.
  • To elucidate the multifaceted roles of senescence in various biological contexts.
  • To explore the therapeutic potential of targeting senescence.

Main Methods:

  • Literature review and synthesis of existing research on cellular senescence.
  • Analysis of gene expression alterations driving senescence.
  • Examination of senescence's impact on tissue functions and pathologies.

Main Results:

  • Senescence is induced by various factors, leading to altered gene expression.
  • It plays contrasting roles in tumor suppression, promotion, wound healing, and aging.
  • Senescence is implicated in significant tissue functions.

Conclusions:

  • Cellular senescence is a key biological process with complex roles.
  • Understanding senescence initiators and pathways is crucial.
  • Targeting senescence presents a promising avenue for novel therapeutic strategies.