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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models
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Chronic, Acute, and Reactivated HIV Infection in Humanized Immunodeficient Mouse Models

Published on: December 3, 2019

Avascular necrosis in HIV patients: a case-control study

G G Whitlock1, S Herbert, A Copas

  • 1Centre for Sexual Health & HIV Research, Research Department of Infection and Population Health, University College London, London, UK.

International Journal of STD & AIDS
|August 24, 2013
PubMed

This study investigates the association of avascular necrosis (AVN) in human immunodeficiency virus (HIV)-positive individuals with possible risk factors, including antiretroviral therapy. Clinic records of all AVN cases diagnosed up to July 2009 in HIV-positive patients attending North Middlesex Hospital, London, UK were retrospectively reviewed. For each case, one control was randomly selected, matched for gender, age, nadir CD4 count and date of HIV diagnosis. Of 15 symptomatic AVN cases identified, eight were in women. Univariate analysis demonstrated significant associations between AVN and a history of systemic steroid use (p = 0.004) and cumulative exposure to protease inhibitor (p = 0.03). Physicians should be aware of the risk of AVN with steroid use, the importance of early diagnosis and avoidance of other risk factors in order to prevent further joint involvement if possible.

Keywords:
AIDSAVNHIVantiretroviral therapyavascular necrosiscase–control studycorticosteroidsosteonecrosisprotease inhibitorsrisk factors

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