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Related Concept Videos

Cadherins in Tissue Organization01:19

Cadherins in Tissue Organization

The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In contrast, determination...
Notch Signaling Pathway03:14

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
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Related Experiment Video

Updated: May 8, 2026

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
09:33

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration

Published on: October 3, 2019

Tissue interactions in neural crest cell development and disease.

Yoshiko Takahashi1, Douglas Sipp, Hideki Enomoto

  • 1Department of Zoology, Graduate School of Science, Kyoto University, Kitashirakawa, Sakyo-ku, Kyoto 606-8502, Japan. yotayota@develop.zool.kyoto-u.ac.jp

Science (New York, N.Y.)
|August 24, 2013
PubMed
Summary
This summary is machine-generated.

Neural crest cells (NCCs) are vital embryonic cells forming the peripheral nervous system. Their interactions with other cells, environmental signals, and pathogens influence development and diseases like neuroblastoma.

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Last Updated: May 8, 2026

Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Published on: October 3, 2019

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Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation
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Analysis of Neural Crest Migration and Differentiation by Cross-species Transplantation

Published on: February 7, 2012

Area of Science:

  • Developmental biology
  • Cell biology
  • Neuroscience

Background:

  • The neural crest is a transient embryonic cell population.
  • Neural crest cells (NCCs) differentiate into diverse cell types, including peripheral nervous system components.
  • Dysfunctional NCCs are linked to diseases like neuroblastoma and Hirschsprung disease.

Purpose of the Study:

  • To elucidate the critical interactions influencing neural crest cell (NCC) behavior.
  • To understand the role of NCC interactions in embryonic development and disease pathogenesis.
  • To highlight the impact of cellular and environmental cues on NCC fate.

Main Methods:

  • Review of recent studies on NCC migration and differentiation.
  • Analysis of inter-cellular interactions involving NCCs and vascular lineages.
  • Examination of environmental signals and microbial pathogen influences on NCCs.

Main Results:

  • NCC interactions with vascular lineages are crucial for their development.
  • Environmental signals and microbial pathogens significantly modulate NCC roles.
  • Understanding these interactions provides insights into NCC contributions to development and disease.

Conclusions:

  • Interactions between NCCs and other cell lineages, environmental factors, and pathogens are key determinants of NCC function.
  • These interactions have significant implications for both normal embryonic development and the etiology of associated diseases.
  • Further research into these complex interactions can inform therapeutic strategies for NCC-related disorders.