Penile intraepithelial neoplasia: important lessons from a case series
1Claude Nicol Centre, Royal Sussex County Hospital, Brighton and Sussex University Hospital NHS Trust, Eastern Road, BN2 5BE Brighton, UK. judith.zhou@imperial.nhs.uk
Abstract:
Seven men presenting to our genitourinary (GU) medicine clinic over a period of 22 months had a histopathological diagnosis of penile intraepithelial neoplasia (PIN). Median duration of symptoms was eight months (range 2-216 months). Macroscopic appearances were different in all cases. All histology was reviewed locally and at a tertiary centre. Six of seven had severe dysplasia (PIN III). Interestingly, only one individual was HIV-positive and one, who was immunocompetent, had multifocal disease. These cases highlight the importance of a full anogenital examination and early biopsy in patients presenting with atypical or persistent penile lesions.
