Related Experiment Video
Updated: May 8, 2026
Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
Published on: January 28, 2020
The correlation between early complications of percutaneous coronary intervention and high sensitive C-reactive
Farshad Roghani1, Ali Mehrabi Koushki, Negin Nezarat
1Assistant Professor, Department of Cardiology, Isfahan University of Medical Sciences, Isfahan, Iran.
Insights
High-sensitivity C-reactive protein (hs-CRP) levels are significantly elevated in patients experiencing early complications after percutaneous coronary intervention (PCI). Elevated hs-CRP may serve as a prognostic marker for identifying patients needing closer monitoring post-PCI.
Area of Science:
- Cardiology
- Clinical Chemistry
Background:
- Cardiovascular diseases, particularly coronary artery disease (CAD), are a leading global cause of mortality.
- Percutaneous coronary intervention (PCI) with stent implantation is a common treatment for CAD, but carries risks of complications.
- High-sensitivity C-reactive protein (hs-CRP) is a potential biomarker for early detection of thrombosis and restenosis after PCI.
Purpose of the Study:
- To evaluate hs-CRP levels in patients following PCI.
- To determine if hs-CRP levels have prognostic value for detecting early stent complications.
Main Methods:
- A descriptive, analytical study conducted with 87 patients undergoing PCI.
- Measurement of hs-CRP levels before and after the procedure.
- Monitoring for early stent complications within 24 hours post-PCI.
Main Results:
- Patients with early stent complications exhibited significantly higher mean hs-CRP levels (3.09 ± 1.8) compared to those without complications (1.36 ± 0.97).
- The difference in hs-CRP levels between the two groups was statistically significant (P < 0.001).
Conclusions:
- A significant difference exists in hs-CRP serum concentrations between patients with and without early stent complications.
- Patients with elevated hs-CRP levels post-PCI require heightened clinical attention and care as per CDC guidelines.
Background:
Increased incidence of cardiovascular diseases, especially coronary artery disease (CAD), during recent decades shows this disease entity to be the leading cause of death in the world. On the other hand many successes were achieved in the treatment of these diseases with new technology, which has its own side effects and threats for the patient. Among these new strategies is percutaneous coronary intervention (PCI), especially with stent implantation. Although coronary stents are effective in the treatment of dissection and prevention of restenosis, many side effects and even death have been observed, from 5-10% per year. Some studies showed that there is a relation between high sensitivity C-reactive protein (hs-CRP), as a laboratory marker for early detection of thrombosis and/or restenosis, and early complications of percutaneous coronary intervention. The aim of this study is to evaluate hs-CRP level in patients after PCI and to investigate if this can be a prognostic value for detection of early complication.
Methods:
This is a descriptive, analytical study done in Shahid Chamran Hospital (Isfahan, Iran) in 2011-2012. 87 patients who had undergone PCI were studied. Their hs-CRP level was measured before and after the study. Moreover, early stent complications were detected during the first 24 hours after insertion. The data was recorded in a researcher-constructed checklist and analyzed by SPSS for Windows 20.
Results:
The mean ± SD of hs-CRP level in patients with and without complication were 1.36 ± 0.97 and 3.09 ± 1.8, respectively. According to Student's t-test, the hs-CRP level in patients with early complications was higher than patients without early complications of stent implantation; the difference was statistically significant (P < 0.001).
Conclusion:
The hs-CRP serum concentrations of patients with, and without early stent complications were significantly different. According to the control diseases center (CDC) guideline, patients with a high level of hs-CRP need special care and attention.
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:30Acute Coronary Syndrome III: Diagnostic Studies
01:30Acute Coronary Syndrome I: Introduction
01:30Coronary Artery Disease I: Introduction
01:19Pericarditis II: Clinical Features and Diagnostic Tests
01:19Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations