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Potential of RAS inhibition to improve metabolic bone disorders

Yoseph Gebru1, Teng-Yue Diao, Hai Pan

  • 1Center for Systems Biomedical Sciences, University of Shanghai for Science and Technology, Shanghai 200093, China.

Biomed Research International
|August 24, 2013
PubMed

Insights

The renin-angiotensin system (RAS) in bone tissue significantly impacts bone metabolism. Inhibiting RAS shows promise for treating metabolic bone disorders and improving bone health.

Area of Science:

  • Biochemistry
  • Endocrinology
  • Bone Biology

Background:

  • Metabolic bone disorders stem from mineral and hormonal imbalances.
  • The local renin-angiotensin system (RAS) in bone is increasingly recognized for its role in bone metabolism.
  • Skeletal RAS activation contributes to the pathogenesis of bone metabolic disorders.

Purpose of the Study:

  • To review the multifaceted roles of the renin-angiotensin system (RAS) in regulating bone metabolism.
  • To explore therapeutic strategies involving RAS inhibition for enhancing bone health.
  • To discuss the clinical implications of targeting RAS for bone disorders.

Main Methods:

  • Review of in vitro, in vivo, and clinical studies.
  • Analysis of the molecular mechanisms underlying RAS involvement in bone.
  • Evaluation of the efficacy of RAS inhibition strategies.

Main Results:

  • Skeletal RAS activation is a key factor in metabolic bone disorders.
  • Inhibition of RAS, primarily by reducing angiotensin II (AngII) levels and signaling, improves bone health.
  • Various RAS inhibitors (renin inhibitors, ACE inhibitors, ARBs) demonstrate potential benefits.

Conclusions:

  • Targeting the renin-angiotensin system offers a promising therapeutic avenue for metabolic bone disorders.
  • RAS inhibition can be beneficial for bone health, both independently and in conjunction with cardiovascular disease treatment.
  • Understanding skeletal RAS pathways is crucial for developing novel bone-protective strategies.

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