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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Magnetic, acidic, ionic liquid-catalyzed one-pot synthesis of spirooxindoles
Ali Khalafi-Nezhad1, Somayeh Mohammadi
1Department of Chemistry, College of Sciences, Shiraz University , Shiraz 71454, Iran.
Abstract:
Magnetic, supported, acidic ionic liquid was synthesized and identified as an efficient catalyst for the one-pot synthesis of novel spirooxindole derivatives at mild conditions and in good yields. Three component reaction of wide variety of substituted isatins, 1,3-dimethyl-2-amino uracil, and barbituric acid, thiobarbituric acid, and dimedon as 1,3-dicarbonyl compounds gives the target compounds. Operational simplicity, low cost, high yields, environmental friendliness, wide applicability and reusability and easy recovery of the catalyst using an external magnet are the key features of this methodology.
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