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Hypertension in children with autosomal dominant polycystic kidney disease (ADPKD)

Melissa A Cadnapaphornchai1

  • 1PKD Research Group, University of Colorado Anschutz Medical Campus, 13001 E. 17th Place, MSC283, Aurora, Colorado 80045, USA. Melissa.Cadnapaphornchai@ucdenver.edu

Current Hypertension Reviews
|August 27, 2013
PubMed

Insights

Autosomal dominant polycystic kidney disease (ADPKD) can affect children, with hypertension being a key risk factor for kidney and heart disease. This review covers current knowledge and pediatric ADPKD hypertension management.

Area of Science:

  • Nephrology
  • Pediatric Hypertension
  • Genetics

Background:

  • Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disorder.
  • Clinical manifestations of ADPKD can begin early in life, including in utero.
  • Hypertension is a significant risk factor for progressive renal and cardiovascular complications in pediatric ADPKD.

Purpose of the Study:

  • To review current knowledge on hypertension in pediatric ADPKD.
  • To discuss established and emerging treatment strategies for managing hypertension in children with ADPKD.

Main Methods:

  • Literature review of current research on ADPKD and pediatric hypertension.
  • Synthesis of information on risk factors, diagnosis, and management of hypertension in pediatric ADPKD.

Main Results:

  • Hypertension is prevalent in children with ADPKD and indicates a risk for irreversible organ damage.
  • Early detection and management of hypertension are crucial for improving outcomes.

Conclusions:

  • Pediatric ADPKD requires comprehensive management strategies that address hypertension.
  • Further research is needed to optimize treatment protocols for hypertension in this population.

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