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Updated: May 8, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Does brachial blood pressure need to predict cardiovascular outcomes in end stage renal disease? An update
Serena Torraca1, Salvatore Palmese, Maria L Sirico
1Nephrology, Medicine Department, A. Landolfi Hospital, Solofra (AV), Italy.
Insights
Hypertension significantly impacts cardiovascular events and kidney disease progression. Current blood pressure measurements may be insufficient for managing hypertension in kidney patients, highlighting the need for a more comprehensive approach.
Area of Science:
- Nephrology
- Cardiology
- Hypertension Research
Background:
- Hypertension is a major contributor to cardiovascular events and a key factor in Chronic Kidney Disease (CKD) progression to End Stage Kidney Disease (ESKD).
- Nephrologists focus on hypertension control in CKD patients to delay progression, but cardiovascular mortality reduction remains poor.
- Adequate blood pressure (BP) reduction is challenging in CKD and dialysis patients, even with multiple medications.
Purpose of the Study:
- To evaluate the sufficiency of brachial blood pressure measurement in assessing the relationship between BP alterations and outcomes in renal patients.
- To explore the significance of blood pressure variability (BPV) in the context of hypertension management in CKD and ESKD.
- To underscore the limitations of current BP measurement methods in capturing the complexity of hypertension in renal disease.
Main Methods:
- Review of existing literature on hypertension management in Chronic Kidney Disease (CKD) and End Stage Kidney Disease (ESKD).
- Analysis of the role of brachial blood pressure (BP) measurements versus other potential indicators.
- Consideration of blood pressure variability (BPV) as a critical, yet often overlooked, factor.
Main Results:
- Brachial BP measurement alone may be insufficient to fully characterize the hypertensive condition in CKD and ESKD patients.
- The complexity of hypertension in renal disease is not adequately captured by standard BP measurements.
- Current approaches may overlook crucial aspects influencing mortality risk in these populations.
Conclusions:
- A more comprehensive assessment of hypertension beyond brachial BP is necessary for CKD and ESKD patients.
- Incorporating factors like blood pressure variability could improve understanding and management of hypertension in renal disease.
- Current limitations in evaluating hypertension complexity contribute to unrecognized aspects of patient care and outcomes.
Abstract:
Hypertension is responsible for a significantly increased burden of cardiovascular events and it is cause and a consequence of Chronic Kidney Disease (CKD) and a determinant factor in its progression to End Stage Kidney Disease (ESKD). Therefore, nephrologists have been focusing their attention on hypertension control to prevent CKD progression, delaying it but with poor results on cardiovascular mortality reduction. An important effect is the difficulty to adequately reduce BP levels in CKD patients and especially in dialysis patients despite the polipharmacological therapy. We have to take into account other aspects influencing mortality risk in CKD patients .The first aspect to consider is whether brachial blood pressure (BP) measurement is sufficient to describe the complex relationship between the alteration of BP and outcomes in renal subjects. The second aspect to consider is the variability of BP (BPV). We think that BP measurement cannot only take into account brachial BP, because it represents a limited measure of a complex clinical condition in CKD or ESRD patients. The inability to evaluate hypertension in its complexity explains why several aspects are still unrecognized.
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