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Updated: May 8, 2026

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids
Published on: December 23, 2022
Primary malignant melanoma of the esophagus: a rare and aggressive disease
Flávio Hiroshi Ananias Morita1, Ulysses Ribeiro, Rubens Antonio Aissar Sallum
1Departments of Gastroenterology/Pathology, Instituto do Câncer do Estado de São Paulo - ICESP, University of São Paulo School of Medicine, São Paulo, Brazil. ulyssesribeiro@terra.com.br.
Abstract:
Primary malignant melanoma of the esophagus is an uncommon tumor, with approximately 300 cases having been reported thus far. The purpose of this study was to describe a case of a 60 year-old man with a 10 month history of progressive dysphagia and thoracic pain, the investigations of which led to a diagnosis of primary malignant melanoma of the esophagus. The patient underwent a transhiatal esophagectomy with subcarinal lymphadenectomy, and isoperistaltic gastric tube replacement of the esophagus. Nine months after surgery, he developed ischemic colitis, and metastasis in the mesentery was diagnosed. His disease progressed and he died one year after the esophagectomy. A review of the literature was performed.
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