[Changes in the functional state of the adrenal glands in experimental bronchospasm in dogs]

Changes in the adrenal functional state were revealed during the development of bronchoconstriction induced by allergen inhalation in 7 dogs sensitized with ovalbumin. The decrease in V1 (expiratory flow-volume) on an average by 58% was noted after inhalation of 1000 microG of ovalbumin. The significant decrease in II-hydroxycorticosteroids (II-OCS), adrenaline, noradrenaline, dopamine, and a tendency to the increase in histamine content were observed in the venous blood plasma. The decrease in the adrenaline content in plasma apparently contribute to the development of early bronchoconstrictor response, and the decrease in II-OCS maintain the development and the progress of late bronchoconstrictor response.