Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intervertebral disk mineralization in progressive ankylosis mice.

H W Sampson1, J P Trzeciakowski

  • 1Department of Anatomy, College of Medicine, Texas A & M University, College Station 77843.

Bone and Mineral
|July 1, 1990
PubMed
Summary

Progressive ankylosis in mice leads to significant changes in intervertebral disk composition, including increased calcium and decreased water and phosphorus. These disk changes were not correlated with serum or bone mineral levels.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Loss of smooth muscle α-actin effects on mechanosensing and cell-matrix adhesions.

Experimental biology and medicine (Maywood, N.J.)·2020
Same author

Increased susceptibility of aging kidney to ischemic injury: identification of candidate genes changed during aging, but corrected by caloric restriction.

American journal of physiology. Renal physiology·2007
Same author

Alcohol's harmful effects on bone.

Alcohol health and research world·2005
Same author

Nonlinear analysis of partial dopamine agonist effects on cAMP in C6 glioma cells.

Journal of pharmacological and toxicological methods·2001
Same author

Adult-onset alcohol consumption induces osteopenia in female rats.

Alcoholism, clinical and experimental research·2001
Same author

The mechanical properties of cancellous bone in the proximal tibia of ovariectomized rats.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research·2000

Area of Science:

  • Biochemistry
  • Orthopedics
  • Mineral Metabolism

Background:

  • Intervertebral disk degeneration is a complex process.
  • Mineralization plays a role in spinal pathologies.
  • Understanding mineral shifts in ankylosis is crucial.

Purpose of the Study:

  • To quantify mineral content changes in the intervertebral disks of mice with progressive ankylosis.
  • To investigate concurrent alterations in serum and bone mineral levels.
  • To establish correlations between disk mineralization and systemic mineral status.

Main Methods:

  • Analysis of intervertebral disk water, calcium, and phosphorus content in ankylosing mice.
  • Measurement of serum calcium and phosphorus levels.
  • Comparison of mineral content between ankylosing disks and vertebral bodies.

Related Experiment Videos

  • Age-dependent analysis of mineral composition changes.

    • Main Results:

    • Intervertebral disks showed a 5.2% decrease in water, a 24% increase in calcium, and a 29% decrease in phosphorus.
    • These compositional changes in disks intensified with age.
    • Vertebral bodies did not exhibit significant differences in mineral or water content.
    • Mineral levels per gram were substantially higher in ankylosing disks than in vertebral bodies.
    • Serum and bone mineral levels remained within normal limits and showed no correlation with disk changes.

    Conclusions:

    • Progressive ankylosis in mice is characterized by significant, age-related mineralization of intervertebral disks.
    • Systemic mineral levels (serum and bone) do not appear to directly influence or correlate with this intra-diskal mineralization.
    • The findings highlight localized mineral metabolic alterations within the intervertebral disk during ankylosis.