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Driving external chemistry optimization via operations management principles
F Christopher Bi1, Heather N Frost2, Xiaolan Ling3
1External Research Solutions, Pfizer Worldwide R&D, San Diego, CA 92121, USA.
Drug Discovery Today
|August 27, 2013
Summary
Pfizer boosted chemistry CRO productivity by implementing Lean Six Sigma and queue management. This led to a 48% reduction in cycle times and a 29% increase in compound flow through workflow optimization and improved processes.
Area of Science:
- Pharmaceutical Sciences
- Operations Management
- Process Improvement
Background:
- Remotely located chemistry Contract Research Organizations (CROs) faced productivity challenges.
- Pfizer sought to enhance efficiency in outsourced chemistry services.
Purpose of the Study:
- To improve productivity and outcomes for remote chemistry CROs.
- To leverage Lean Six Sigma and queue management principles for measurable results.
Main Methods:
- Conducted detailed workflow analysis to identify and resolve bottlenecks.
- Optimized work in progress (WIP) and the request process.
- Implemented strategies to de-risk chemistry processes.
- Fostered collaborative relationships and communication between Pfizer and CRO chemists.
Main Results:
- Achieved a 48% reduction in cycle times during 2012.
- Increased compound flow by 29%.
- Demonstrated positive, measurable outcomes through continuous improvement initiatives.
Conclusions:
- Integration of Lean Six Sigma and queue management effectively enhanced CRO productivity.
- Workflow optimization and improved communication are key to reducing cycle times and increasing compound flow.
- Collaborative partnerships are essential for success in outsourced chemistry operations.
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