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Updated: May 8, 2026

High-definition Fourier Transform Infrared (FT-IR) Spectroscopic Imaging of Human Tissue Sections towards Improving Pathology
Published on: January 21, 2015
Comparison of serum from gastric cancer patients and from healthy persons using FTIR spectroscopy
Daping Sheng1, Yican Wu, Xin Wang
1School of Nuclear Science and Technology, University of Science and Technology of China, Hefei, Anhui 230027, China; The First Affiliated Hospital, Anhui Medical University, Hefei, Anhui 230032, China.
Abstract:
Since serum can reflect human beings' physiological and pathological conditions, FTIR spectroscopy was used to compare gastric cancer patients' serum with healthy persons' serum in this study. The H2959/H2931, H1646/H1550, H1314/H1243, H1453/H1400 and H1080/H1550 ratios were calculated, among these ratios, the H2959/H2931 ratio might be a standard for distinguishing gastric cancer patients from healthy persons. Then curve fitting was processed using Gaussian curves in the 1140-1000 cm(-1) region, and the result showed that the RNA/DNA ratios of gastric cancer patients' serum were obviously lower than those of healthy persons' serum. The results suggest that FTIR spectroscopy may be a potentially useful tool for diagnosis of gastric cancer.
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