Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The positive:negative dichotomy in schizophrenia.

A M Mortimer1, C E Lund, P J McKenna

  • 1University of Leeds.

The British Journal of Psychiatry : the Journal of Mental Science
|July 1, 1990
PubMed
Summary

Schizophrenia symptoms do not correlate, suggesting distinct symptom clusters. Formal thought disorder and catatonic motor disorder in schizophrenia may have positive and negative symptom divisions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Update on the Royal College of Radiologists sponsored credential Mechanical Thrombectomy for Acute Ischaemic Stroke: thoughts about implementation in an under-resourced environment.

Clinical radiology·2023
Same author

Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies.

PloS one·2021
Same author

Carryover effects on the clonal growth of the grass Holcus lanatus L.

The New phytologist·2021
Same author

Reward and fictive prediction error signals in ventral striatum: asymmetry between factual and counterfactual processing.

Brain structure & function·2021
Same author

Electroencephalographic (EEG) features of encephalopathy in the setting of Covid-19: A case series.

Clinical neurophysiology practice·2020
Same author

Anaesthetic preferences for endovascular stroke thrombectomy.

Anaesthesia·2020

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Schizophrenia is a complex mental disorder characterized by a wide range of symptoms.
  • Symptoms are often broadly categorized into positive, negative, and disorganization domains.
  • The precise relationships and potential subdivisions within these symptom categories require further investigation.

Purpose of the Study:

  • To investigate the relationship between positive and negative symptoms in schizophrenia.
  • To determine if specific symptom clusters, such as formal thought disorder and catatonic motor disorder, can be divided based on positive and negative symptom correlations.
  • To explore the potential for a third 'disorganization' class of schizophrenic symptoms.

Main Methods:

  • Two studies were conducted with schizophrenic patients.
  • Symptom severity was assessed using blind ratings.
  • Statistical analyses, including factor and cluster analyses, were employed to examine symptom correlations.

Main Results:

  • No significant correlation was found between negative and positive symptom scores in the first study.
  • Formal thought disorder clearly separated into 'positive formal thought disorder' and 'alogia' syndromes in the second study.
  • Catatonic motor disorder showed a positive: negative division when illness severity or chronicity was controlled; cognitive impairment's correlation with negative symptoms may be artefactual.

Conclusions:

  • Schizophrenia symptom presentation may be more heterogeneous than previously assumed.
  • Formal thought disorder and catatonic motor disorder exhibit distinct positive and negative symptom profiles.
  • Further research is needed to clarify the 'disorganization' symptom class and the nature of cognitive impairment in schizophrenia.

Related Experiment Videos