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Effect of Artificial Tear Formulations on the Metabolic Activity of Human Corneal Epithelial Cells after Exposure to Desiccation
Published on: May 2, 2020
Tear film stability: a review.
Deborah F Sweeney1, Thomas J Millar, Shiwani R Raju
1Office of the Pro-Vice Chancellor, University of Western Sydney, Locked Bag 1797, Sydney, Penrith, 2751 NSW, Australia.
Experimental Eye Research
|August 27, 2013
Summary
This review explores methods for assessing tear film stability, crucial for understanding dry eye disease and guiding treatment. It covers various techniques and factors influencing tear film integrity.
Area of Science:
- Ophthalmology and Vision Science
- Biomedical Engineering
- Surface Science
Background:
- Tear film instability is a primary cause of dry eye disease, potentially leading to ocular surface damage and vision impairment.
- Accurate assessment of tear film stability is vital for diagnosing dry eye and evaluating therapeutic interventions.
- Understanding the factors contributing to tear film instability is essential for developing effective management strategies.
Purpose of the Study:
- To provide a comprehensive review of current techniques used for assessing tear film instability.
- To discuss the influence of various tear film components and external factors on tear film stability.
- To highlight the importance of tear film assessment in clinical practice and research.
Main Methods:
- Review of established and emerging methods for tear film stability assessment.
- Analysis of techniques including tear break-up time (TBUT) and non-invasive break-up time (NIBUT).
- Inclusion of advanced methods like topography, interferometry, confocal microscopy, aberrometry, and visual function tests.
Main Results:
- Various clinical and research tools effectively assess tear film stability.
- Tear film instability is influenced by meibomian lipids, mucins, proteins, age, contact lens wear, surgery, and environmental factors.
- Different assessment techniques offer unique insights into the complex nature of the tear film.
Conclusions:
- A range of techniques are available for evaluating tear film stability, aiding in the diagnosis and management of dry eye.
- Multiple intrinsic and extrinsic factors significantly impact tear film integrity.
- Further research into tear film dynamics and assessment methods is crucial for advancing ocular surface health.
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