Tetraphenylethene-based aggregation-induced emission fluorescent organic nanoparticles: facile preparation and cell
Xiqi Zhang1, Meiying Liu, Bin Yang
1Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Tsinghua University, Beijing 100084, PR China.
Abstract:
Tetraphenylethene-based (TPE) aggregation-induced emission fluorescent organic nanoparticles (FONs) were facilely prepared via Schiff base condensation with ɛ-polylysine (Ply) and subsequent reduction to form stable CN covalent bond. Thus obtained TPE-Ply FONs were characterized by a series of techniques including fluorescent spectroscopy, Fourier transform infrared spectroscopy and transmission electron microscopy. Biocompatibility evaluation and cell uptake behavior of TPE-Ply FONs were further investigated to explore their potential biomedical application. We demonstrated that such FONs showed high water dispersibility, intense fluorescence, uniform morphology (100-200nm) and excellent biocompatibility, making them promising for cell imaging application.
