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Updated: May 8, 2026

Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
Published on: March 6, 2019
Synthesis and anti-HBV activity of novel 3'-N-phenylsulfonyl docetaxel analogs
Jun Chang1, Yun-Peng Hao, Xiao-Dong Hao
1Department of Natural Products Chemistry, School of Pharmacy, Fudan University, Shanghai 201203, China.
Abstract:
Nine new 3'-N-phenylsulfonyl docetaxel analogs were synthesized in good yields from the key intermediate N-phenylsulfonyl oxazolidine via a six-step route. These analogs were tested for anti-hepatitis B virus (HBV) activity in vitro. Compounds 3e, 3g and 3j showed more potent inhibitory activity against HBeAg secretion than the positive control lamivudine. Further extensive SAR and mechanistic studies will be reported in due course.

