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The Cooperative Lifestyle Intervention Program-II (CLIP-II): design and methods
Anthony P Marsh1, James A Janssen, Walter T Ambrosius
1Department of Health and Exercise Science, Wake Forest University, Winston-Salem, NC 27109, USA.
Contemporary Clinical Trials
|August 27, 2013
Summary
This study investigated weight loss and exercise in older adults with cardiovascular disease or metabolic syndrome. Combining weight loss with aerobic or resistance training improved mobility and strength more than weight loss alone.
Area of Science:
- Gerontology
- Cardiovascular Health
- Metabolic Health
Background:
- Mobility loss is a complication of cardiovascular disease (CVD) and metabolic syndrome (MetS) in older adults.
- Weight management is crucial for CVD secondary prevention and reducing physical disability risk.
- Long-term trials are needed to assess diet-induced weight loss (WL) and physical activity effects on mobility and muscle function in older adults.
Purpose of the Study:
- To evaluate the effects of weight loss (WL) alone versus WL combined with aerobic training (AT) or resistance training (RT) on mobility and muscle strength in obese older adults with CVD or MetS.
- To provide the first large-scale trial comparing WL, AT+WL, and RT+WL in this population.
- To assess the impact of different exercise modalities on lean mass preservation during weight loss.
Main Methods:
- The Cooperative Lifestyle Intervention Program-II (CLIP-II) randomized 252 obese older adults with CVD or MetS.
- Participants were assigned to WL only, AT+WL, or RT+WL for 18 months.
- Dual primary outcomes were mobility and knee extensor strength, with interventions delivered via community partners.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- This section is not available in the provided abstract.
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