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Related Concept Videos

Teeth01:15

Teeth

The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin and...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Dosage Regimens: Designs and Approaches01:28

Dosage Regimens: Designs and Approaches

Designing a dosage regimen, which refers to the manner of drug administration, is a complex process involving the selection of drug dose, route, and frequency. This process is underpinned by pharmacokinetic parameters derived from tests and population averages. These parameters are then tailored to patient-specific variables such as diagnosis, demographics, and allergy status. Once therapy commences, therapeutic response monitoring is critical and achieved through clinical and physical...
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
One-Compartment Open Model for IV Bolus Administration: General Considerations01:19

One-Compartment Open Model for IV Bolus Administration: General Considerations

The one-compartment model is a pharmacokinetic tool that models the body as a single, uniform compartment, facilitating the understanding of drug distribution and elimination. This model is particularly beneficial for intravenous (IV) bolus administration, where the drug rapidly circulates throughout the body.
The drug's presence in the body is defined by an equation representing the difference between the rates of drug entry and exit. Key parameters—elimination rate constant, half-life,...
Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules01:18

Formulation and Manufacturing Process: Physical Attributes of Generic Tablets and Capsules

Bioequivalence in generic drugs, such as tablets and capsules, refers to their pharmaceutical equivalence to the brand-name counterparts. However, for therapeutic equivalence, manufacturers must also consider physical attributes like size, shape, and weight (FDA Guidance for Industry, December 2003). Discrepancies in these aspects could impact patient compliance and cause medication errors. For instance, swallowing difficulties, often experienced with larger tablets or capsules, can lead to...

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Basics for compounding for dentistry, part 1: effective approaches and formulations.

Simonne Fonseca1

  • 1CompoundingToday.com, Pearland, Texas.

International Journal of Pharmaceutical Compounding
|August 27, 2013
PubMed
Summary

Pharmacists play a growing role in dental compounding, creating personalized treatments for oral and head/neck conditions. This includes mouthwashes, pastes, and specialized endodontic solutions.

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Area of Science:

  • Oral medicine and pharmacology.
  • Dental therapeutics and drug delivery.

Background:

  • Modern dentistry addresses a broader scope of head and neck conditions.
  • Patient demand for personalized treatments is increasing.

Purpose of the Study:

  • To highlight the expanding role of pharmacists in dental compounding.
  • To provide examples of compounded dental preparations.

Main Methods:

  • Review of current dental practice and compounding trends.
  • Categorization of compounded formulations based on application.

Main Results:

  • Compounded formulations are primarily for direct oral application (mouthwashes, pastes, powders).
  • Specialized solutions for endodontic procedures require professional compounding.
  • Examples of various compounded preparations are detailed.

Conclusions:

  • Dental compounding offers expanding opportunities for pharmacists.
  • Tailored pharmaceutical preparations enhance dental treatment options.
  • Pharmacists are integral to providing individualized dental care solutions.