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Updated: May 8, 2026

Methods for Analyzing the Impacts of Natural Uranium on In Vitro Osteoclastogenesis
Published on: January 30, 2018
Uranium deposition in bones of Wistar rats associated with skeleton development
G Rodrigues1, J D T Arruda-Neto, R M R Pereira
1Physics Institute University of São Paulo, São Paulo-SP, Brazil; Veterinary Medicine School, Methodist University, São Paulo-SP, Brazil.
Abstract:
Sixty female Wistar rats were submitted to a daily intake of ration doped with uranium from weaning to adulthood. Uranium in bone was quantified by the SSNTD (solid state nuclear track detection) technique, and bone mineral density (BMD) analysis performed. Uranium concentration as a function of age exhibited a sharp rise during the first week of the experiment and a drastic drop of 70% in the following weeks. Data interpretation indicates that uranium mimics calcium. Results from BMD suggest that radiation emitted by the incorporated Uranium could induce death of bone cells.
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