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Related Concept Videos

Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight, compared...

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Innovations in Medication Preparation Safety and Wastage Reduction: Use of a Workflow Management System in a Pediatric Hospital.

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Evaluating the Effects of Different Polishing Methods on Color Stability of Dental Restorations in Pediatric Dentistry
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Pediatric oral formulations: a continual challenge.

Josephine Hurtado1

  • 1Texas Children's Hospital, Department of Pharmacy, Houston, Texas.

International Journal of Pharmaceutical Compounding
|August 27, 2013
PubMed
Summary

Compounding medications for pediatric patients is crucial due to limited commercial options. Pharmacists must ensure reliable formulations, appropriate excipients, and consistent strength and stability for safe and effective pediatric drug preparation.

Area of Science:

  • Pharmaceutical Sciences
  • Pediatric Pharmacology

Background:

  • Limited availability of commercially produced liquid medications for pediatric use necessitates drug compounding.
  • Drug compounding is essential for providing pediatric patients with necessary medications in appropriate forms.

Purpose of the Study:

  • To highlight the importance of drug compounding in pediatric medicine.
  • To emphasize the critical role of pharmacists in ensuring the quality and safety of compounded pediatric medications.

Main Methods:

  • This study is a review of current practices and challenges in pediatric drug compounding.
  • Analysis of existing literature on medication formulation and standardization for children.

Main Results:

  • Lack of reliable information and standardized protocols are significant barriers in pediatric drug compounding.

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  • Compounded medications are vital for pediatric treatment when commercial options are insufficient.

    • Conclusions:

    • Pharmacists must prioritize the use of reliable formulations and appropriate excipients in pediatric compounding.
    • Ensuring consistent strength and stability of compounded medications is paramount for patient safety in pediatric care.