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Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Introduction to the Human Microbiota01:22

Introduction to the Human Microbiota

Microorganisms colonize various regions of the human body, including the mouth, nasal passages, throat, stomach, intestines, urogenital tract, and skin. The total number of microbial cells is estimated to range from 10¹³ to 10¹⁴—comparable to, or exceeding, the number of human somatic cells. This host–microbiome relationship has led to the conceptualization of humans as supraorganisms, wherein microbial communities perform vital roles in development, immunity, and disease...
The Oral Microbiota01:27

The Oral Microbiota

The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...
Functions of the Gut Microbiota01:18

Functions of the Gut Microbiota

The gut microbiota includes trillions of microorganisms that colonize the human gastrointestinal tract, including bacteria, archaea, viruses, and fungi. This complex ecosystem plays a critical role in maintaining intestinal and systemic health. Most of these microbes inhabit the large intestine, establishing a relatively stable and diverse community that contributes to gut homeostasis through various metabolic, immunological, and protective mechanisms.Dominant bacterial phyla, such as...

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
11:22

Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

Microbiome and skin diseases.

Patrick L J M Zeeuwen1, Michiel Kleerebezem, Harro M Timmerman

  • 1Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.

Current Opinion in Allergy and Clinical Immunology
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

The skin microbiome, comprising diverse microbes on human skin, plays a crucial role in health and diseases like atopic dermatitis and psoriasis. Understanding and modulating this microbial community offers potential therapeutic strategies for skin conditions.

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Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction
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Published on: November 6, 2019

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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing

Published on: October 15, 2019

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Published on: November 6, 2019

Area of Science:

  • Microbiology
  • Dermatology
  • Immunology

Background:

  • The human skin harbors a complex microbial community, the skin microbiome.
  • This microbiome is increasingly recognized for its role in maintaining skin health and influencing disease states.

Purpose of the Study:

  • To review recent advancements in understanding the skin microbiome.
  • To update knowledge on the role of skin microbiota in healthy skin and in inflammatory and allergic skin diseases.

Main Methods:

  • Utilizing advances in computing and high-throughput sequencing technologies.
  • Analyzing microbiota composition and functionality in both healthy and diseased skin.

Main Results:

  • High diversity and interpersonal variation characterize the normal skin microbiome.
  • Diseased skin (atopic dermatitis, psoriasis) exhibits distinct microbiota compositions compared to healthy skin.
  • Emerging strategies aim to manipulate the skin microbiome to modulate disease symptoms.

Conclusions:

  • Host-microbe interactions and genetic factors influence skin dysbiosis.
  • Restoring skin microbiota homeostasis presents a potential future therapeutic strategy for skin disorders.
  • The skin microbiome's function in immune system homeostasis is critical for cutaneous health.