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Translocation between chromosomes 8q24 and 14q11 in T-cell acute lymphoblastic leukemia
1Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Cancer Genetics and Cytogenetics
|October 1, 1990
Abstract:
Cytogenetic study was performed on a patient with T-cell acute lymphoblastic leukemia (T-ALL). It revealed a chromosomal translocation between chromosome bands 8q24 and 14q11. 8q24 is known to encode the oncogene c-myc, while 14q11 encodes the genes for T-cell receptor-alpha (TCR-alpha) and T-cell receptor-delta (TCR-delta). Therefore, this chromosomal translocation t(8;14) (q24;q11) seemed to be unique and specific to T-cell malignancy.
