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Updated: May 8, 2026
07:35
Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
Published on: June 8, 2020
Potential targets for colorectal cancer prevention
Sally Temraz1, Deborah Mukherji, Ali Shamseddine
1Division of Hematology/Oncology, American University of Beirut Medical Center, Beirut 1107 2020, Lebanon. st29@aub.edu.lb
International Journal of Molecular Sciences
|August 27, 2013
Summary
Chemopreventive agents like curcumin, resveratrol, and quercetin show promise in delaying colorectal cancer. These natural compounds target key pathways involved in cancer development, offering a potential alternative to toxic drugs.
Area of Science:
- Oncology
- Molecular Biology
- Gastroenterology
Background:
- Colorectal cancer develops progressively from adenoma to carcinoma.
- Key molecular pathways in colorectal cancer pathogenesis include COX-2, NF-κB, survivin, and IGF-I.
- COX-2 inhibitors demonstrated potential for chemoprevention but have toxicity concerns.
Purpose of the Study:
- To explore natural chemopreventive agents for colorectal cancer.
- To identify compounds that can suppress multiple carcinogenic signaling pathways.
Main Methods:
- Review of existing research on colorectal cancer pathogenesis.
- Analysis of the mechanisms of action for curcumin, resveratrol, and quercetin.
Main Results:
- Cyclooxygenase 2 (COX-2) inhibitors show efficacy but limited use due to toxicity.
- Curcumin, resveratrol, and quercetin target multiple cancer-related signaling pathways.
- These agents represent promising candidates for colorectal cancer chemoprevention.
Conclusions:
- Natural compounds like curcumin, resveratrol, and quercetin offer a safer alternative for colorectal cancer chemoprevention.
- Targeting multiple pathways with these agents may effectively delay or prevent colorectal neoplasia progression.
- Further research into these agents is warranted for their clinical application.
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