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Updated: May 8, 2026

Production, Characterization and Potential Uses of a 3D Tissue-engineered Human Esophageal Mucosal Model
Published on: May 18, 2015
A microcontinuum model for mechanical properties of esophageal tissue: experimental methodology and constitutive
D Sanchez-Molina1, J Velazquez-Ameijide, C Arregui-Dalmases
1Universitat Politècnica de Catalunya-Barcelona Tech, Barcelona, Spain, david.sanchez-molina@upc.edu.
Abstract:
Accurate material properties of tissues are a key factor for the improvement of medical procedures and treatments. Experimental data are essential in order to formulate and validate a useful constitutive model for predicting the mechanical behavior of tissues in these procedures. This study develops a comprehensive experimental protocol at multiple length scale levels in order to obtain stress-strain curves for esophagus tissue. This paper compares two different models: a conventional, non-linear elastic model, and a microcontinuum model based on fiber rearrangement. Also, a detailed description of the experimental procedure is provided. While the focus was on esophageal tissues, the experimental procedure and microcontinuum are considered widely applicable to other samples of soft tissue.
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