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Related Concept Videos

Bone Cells and Tissue01:30

Bone Cells and Tissue

Bones contain a relatively small number of cells entrenched in a matrix of organic and inorganic components. Although bone cells compose only a small amount of the bone volume, they are crucial to its function. Four types of cells are found within the bone tissue— osteoblasts, osteocytes, osteogenic cells, and osteoclasts.
Osteoblasts and Osteocytes
The osteoblast is the bone cell responsible for forming new bone tissue. It is found in the growing portions of bone, including the periosteum and...
Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 8, 2026

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma
08:07

Three-Dimensional Bone Extracellular Matrix Model for Osteosarcoma

Published on: April 12, 2019

Atypical osteoid osteomas.

Mert Ciftdemir1, Sedat A Tuncel, Ufuk Usta

  • 1Department of Orthopaedic Surgery, Trakya University School of Medicine, Balkan Yerleskesi, 22030, Edirne, Turkey, dr.mert@gmail.com.

European Journal of Orthopaedic Surgery & Traumatology : Orthopedie Traumatologie
|August 27, 2013
PubMed
Summary

Osteoid osteoma is a painful benign bone tumor. Atypical osteoid osteomas present unique diagnostic and treatment challenges due to varied clinical and radiologic features, often leading to misdiagnosis or overtreatment.

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Area of Science:

  • Orthopedics
  • Oncology
  • Radiology

Background:

  • Osteoid osteoma is a benign bone tumor primarily affecting young adults, characterized by intense pain.
  • It can occur anywhere in the skeleton, with typical presentations including intracortical, juxtacortical, or cancellous locations.

Purpose of the Study:

  • To provide general information on classical osteoid osteoma.
  • To discuss the pathogenesis of osteoid osteoma.
  • To focus on the clinical presentation, radiologic features, and treatment of atypical osteoid osteomas.

Main Methods:

  • Literature review of classical and atypical osteoid osteomas.
  • Analysis of clinical and radiologic characteristics.
  • Review of current treatment modalities.

Main Results:

  • Atypical osteoid osteomas deviate from classical presentations, complicating diagnosis and treatment.
  • Misdiagnosis of atypical osteoid osteomas can lead to prolonged impairment or overtreatment.
  • Understanding specific features of atypical osteoid osteomas is crucial for appropriate management.

Conclusions:

  • Atypical osteoid osteomas require careful diagnostic evaluation due to their varied presentations.
  • Accurate identification of atypical osteoid osteomas is essential to avoid misdiagnosis and ensure effective treatment.
  • This review highlights the importance of recognizing atypical presentations for optimal patient outcomes.