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Updated: May 8, 2026

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow
12:54

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow

Published on: September 4, 2014

Seeing stem cells at work in vivo

Amit K Srivastava1, Jeff W M Bulte

  • 1Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD, 21205-1832, USA.

Stem Cell Reviews and Reports
|August 27, 2013
PubMed

Insights

Stem cell therapies offer new treatment potential but require in vivo tracking. This review details advanced cellular imaging techniques for monitoring transplanted stem cells to assess therapy efficacy and safety.

Area of Science:

  • Regenerative Medicine
  • Biomedical Imaging
  • Cell Biology

Background:

  • Stem cell-based therapies represent promising treatments for diseases with limited options.
  • The long-term safety and efficacy of these novel therapies remain largely undetermined.
  • In vivo monitoring of transplanted cells is crucial for understanding their fate and therapeutic impact.

Purpose of the Study:

  • To review current advancements in stem cell labeling and tracking technologies.
  • To highlight the role of non-invasive imaging in evaluating stem cell therapy effectiveness.
  • To provide insights into methods for monitoring cell distribution, differentiation, and longevity post-transplantation.

Main Methods:

  • Review of recent literature on stem cell labeling techniques.
  • Analysis of various non-invasive cellular imaging modalities for in vivo tracking.
  • Discussion of methods for assessing engrafted cell fate over time.

Main Results:

  • Significant progress has been made in developing sophisticated stem cell labeling strategies.
  • Non-invasive imaging techniques enable real-time monitoring of transplanted cells within a living organism.
  • These tracking methods are essential for validating the success of stem cell therapies.

Conclusions:

  • Advanced cellular imaging is indispensable for the rigorous evaluation of stem cell therapies.
  • Continued development in labeling and tracking technologies will accelerate the clinical translation of stem cell treatments.
  • Understanding the in vivo behavior of stem cells is key to maximizing therapeutic benefits and ensuring patient safety.

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