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Related Concept Videos

Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Renewal of Intestinal Stem Cells01:23

Renewal of Intestinal Stem Cells

The intestinal epithelial lining rapidly renews every 4 to 5 days. The renewal is facilitated by intestinal stem cells (ISCs) located at the base of the crypt– a gland located at the bottom of each villus. ISCs divide asymmetrically to form new stem cells and progenitor daughter cells. The daughter cells are called transit-amplifying (TA) cells which move upwards along the crypt and either differentiate into absorptive cells– the enterocytes or secretory cells– including the goblet,...
Source And Potency Of Stem Cells01:27

Source And Potency Of Stem Cells

Stem cells are undifferentiated cells with extensive self-renewal properties that help them maintain their population during the fetal and adult stages of life. They can specialize in all cell types of the human body. However, their differential potential may vary and can be classified into five types. Stem cells can be (1) Totipotent, (2) Pluripotent, (3) Multipotent, (4) Oligopotent, and (5) Unipotent. Each stem cell has a specific origin; the fertilized egg or zygote is a totipotent cell and...

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Related Experiment Video

Updated: May 8, 2026

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow
12:54

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow

Published on: September 4, 2014

Seeing stem cells at work in vivo.

Amit K Srivastava1, Jeff W M Bulte

  • 1Russell H. Morgan Department of Radiology and Radiological Science, Division of MR Research, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD, 21205-1832, USA.

Stem Cell Reviews and Reports
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Stem cell therapies offer new treatment potential but require in vivo tracking. This review details advanced cellular imaging techniques for monitoring transplanted stem cells to assess therapy efficacy and safety.

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In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
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In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

Related Experiment Videos

Last Updated: May 8, 2026

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow
12:54

In Vivo 4-Dimensional Tracking of Hematopoietic Stem and Progenitor Cells in Adult Mouse Calvarial Bone Marrow

Published on: September 4, 2014

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy
17:08

In vivo Clonal Tracking of Hematopoietic Stem and Progenitor Cells Marked by Five Fluorescent Proteins using Confocal and Multiphoton Microscopy

Published on: August 6, 2014

Area of Science:

  • Regenerative Medicine
  • Biomedical Imaging
  • Cell Biology

Background:

  • Stem cell-based therapies represent promising treatments for diseases with limited options.
  • The long-term safety and efficacy of these novel therapies remain largely undetermined.
  • In vivo monitoring of transplanted cells is crucial for understanding their fate and therapeutic impact.

Purpose of the Study:

  • To review current advancements in stem cell labeling and tracking technologies.
  • To highlight the role of non-invasive imaging in evaluating stem cell therapy effectiveness.
  • To provide insights into methods for monitoring cell distribution, differentiation, and longevity post-transplantation.

Main Methods:

  • Review of recent literature on stem cell labeling techniques.
  • Analysis of various non-invasive cellular imaging modalities for in vivo tracking.
  • Discussion of methods for assessing engrafted cell fate over time.

Main Results:

  • Significant progress has been made in developing sophisticated stem cell labeling strategies.
  • Non-invasive imaging techniques enable real-time monitoring of transplanted cells within a living organism.
  • These tracking methods are essential for validating the success of stem cell therapies.

Conclusions:

  • Advanced cellular imaging is indispensable for the rigorous evaluation of stem cell therapies.
  • Continued development in labeling and tracking technologies will accelerate the clinical translation of stem cell treatments.
  • Understanding the in vivo behavior of stem cells is key to maximizing therapeutic benefits and ensuring patient safety.