Related Experiment Video
Updated: May 8, 2026

Assessment of Child Anthropometry in a Large Epidemiologic Study
Published on: February 2, 2017
Underweight, overweight and obesity in paediatric dialysis and renal transplant patients
Marjolein Bonthuis1, Karlijn J van Stralen, Enrico Verrina
1ESPN/ERA-EDTA Registry, Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Insights
Overweight and obesity are common in European children on renal replacement therapy (RRT), challenging the focus on malnutrition. Nutritional strategies must address both underweight and overweight/obesity in pediatric RRT patients.
Area of Science:
- Pediatric Nephrology
- Public Health
- Nutritional Science
Background:
- Childhood overweight is a global concern, yet poor nutrition remains primary in pediatric renal replacement therapy (RRT).
- This study investigates the prevalence and factors of underweight and overweight/obesity in European children undergoing RRT.
- It also examines body mass index (BMI) changes post-RRT initiation.
Purpose of the Study:
- To determine the prevalence of underweight, overweight, and obesity in European children on RRT.
- To identify factors associated with underweight and overweight/obesity in this population.
- To analyze the changes in BMI after starting RRT.
Main Methods:
- Analysis of BMI data from 4474 European pediatric RRT patients (1995-2010).
- Utilized World Health Organization (WHO) and International Obesity Task Force (IOTF) criteria for BMI classification.
- Data sourced from the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry.
Main Results:
- Underweight prevalence was 3.5%; overweight was 20.8%; obesity was 12.5%.
- Dialysis treatment and infant age were linked to underweight.
- Short stature and glucocorticoid use were associated with overweight/obesity in transplant recipients.
Conclusions:
- Overweight and obesity are more prevalent than underweight in European pediatric RRT patients.
- Short stature is strongly linked to overweight in graft recipients; underweight is primarily an infant issue.
- Nutritional management for pediatric RRT should equally address overweight/obesity prevention and treatment alongside malnutrition.
Background:
The prevalence of childhood overweight is rising worldwide, but in children on renal replacement therapy (RRT) a poor nutritional status is still the primary concern. We aimed to study the prevalence of, and factors associated with, underweight and overweight/obesity in the European paediatric RRT population. Moreover, we assessed the evolution of body mass index (BMI) after the start of RRT.
Methods:
We included 4474 patients younger than 16 years from 25 countries of whom BMI data, obtained between 1995 and 2010, were available within the European Society for Paediatric Nephrology/European Renal Association-European Dialysis and Transplant Association Registry. Prevalence estimates for under- and overweight/obesity were calculated using age and sex-specific criteria of the World Health Organization (WHO, 0-1 year olds) and the International Obesity Task Force cut-offs (2-15 year olds).
Results:
The prevalence of underweight was 3.5%, whereas 20.8% of the patients were overweight and 12.5% obese. Factors associated with being underweight were receiving dialysis treatment and infant age. Among transplanted recipients, a very short stature (OR: 1.64, 95% CI: 1.40-1.92) and glucocorticoid treatment (OR: 1.23, 95% CI: 1.03-1.47) were associated with a higher risk of being overweight/obese. BMI increased post-transplant, and a lower BMI and a higher age at the start of RRT were associated with greater BMI changes during RRT treatment.
Conclusions:
Overweight and obesity, rather than underweight, are highly prevalent in European children on RRT. Short stature among graft recipients had a strong association with overweight, while underweight appears to be only a problem in infants. Our findings suggest that nutritional management in children receiving RRT should focus as much on the prevention and treatment of overweight as on preventing malnutrition.
Related Concept Videos
Chronic Kidney Disease III: Interprofessional Care
Kidney Transplant I: Introduction
Drug Dosing: Obese Patients
Kidney Transplant III: Nursing Management
Acute Kidney Injury V: Interprofessional Care
Kidney Transplant II: Surgical Procedure
