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Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their access...

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Updated: May 8, 2026

Ultrasound-guided Intracardiac Injection of Human Mesenchymal Stem Cells to Increase Homing to the Intestine for Use in Murine Models of Experimental Inflammatory Bowel Diseases
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Mesenchymal stem cells as a vector for the inflammatory prostate microenvironment.

W Nathaniel Brennen1, Samuel R Denmeade, John T Isaacs

  • 1Chemical Therapeutics Program, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland 21287, USA.

Endocrine-Related Cancer
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Mesenchymal stem cells (MSCs) home to inflammation, including prostate cancer sites. Their immunomodulatory and tumor-promoting roles suggest potential as therapeutic delivery vectors.

Keywords:
MSCinflammationmesenchymal stem cellmultipotent stromal cellprostate cancer

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Area of Science:

  • Immunology
  • Oncology
  • Stem Cell Biology

Background:

  • Mesenchymal stem cells (MSCs) are CD73/CD90/CD105 triple-positive cells with multi-lineage differentiation potential.
  • MSCs exhibit immunoprivileged status and immunomodulatory effects on innate and adaptive immunity.
  • Chronic inflammation is implicated in prostate carcinogenesis, and MSCs may influence this process.

Purpose of the Study:

  • To investigate the role of MSCs in prostate cancer.
  • To explore the potential of MSCs as therapeutic delivery vectors.

Main Methods:

  • Analysis of MSC presence in human prostatectomy tissue.
  • Review of existing literature on MSCs in cancer progression and therapy.

Main Results:

  • MSCs constitute 0.01-1.1% of cells in human prostatectomy tissue.
  • MSCs can promote tumor proliferation, angiogenesis, survival, and metastasis.
  • Human bone marrow-derived MSCs traffic to prostate cancer xenografts.

Conclusions:

  • MSCs play a complex role in prostate cancer, potentially mediating immune responses and influencing malignant progression.
  • The unique properties of MSCs, including tropism and immunoprivilege, make them promising candidates for cell-based cancer therapies.