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Related Concept Videos

Autophagy01:27

Autophagy

Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
Delivery Pathways to the Lysosome01:36

Delivery Pathways to the Lysosome

Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Autophagic Cell Death01:18

Autophagic Cell Death

Christian de Duve discovered “autophagy,” a process in which cellular components are engulfed by membrane-bound organelles called autophagosomes. The autophagosomes then fuse with lysosomes to digest the enclosed contents. Autophagy is generally activated in cells to prevent cell death. However, cell death is triggered when the damage is beyond repair.
Autophagy and Apoptosis
Autophagy can activate apoptosis. In normal conditions, the autophagy activating protein Beclin-1 and pro-apoptotic...
Cellular Injury V: Apoptosis and Autophagy01:22

Cellular Injury V: Apoptosis and Autophagy

Cells respond to damage and stress through highly coordinated processes that decide whether they survive or undergo controlled self-destruction. Two major pathways involved in this regulation are apoptosis, a type of programmed cell death, and autophagy, a survival mechanism that helps cells adapt to adverse conditions.ApoptosisApoptosis removes aged or injured cells to maintain tissue balance. During this process, the cell shrinks, chromatin condenses and fragments, and membrane-bound...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...

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Related Experiment Video

Updated: May 8, 2026

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy
07:20

Exploring the Regulation of Lipid Droplet Catabolism through Lipophagy

Published on: January 31, 2025

Autophagy and cancer.

Si-Zhao Lu1, Duygu Dee Harrison-Findik

  • 1Si-Zhao Lu, Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, United States.

World Journal of Biological Chemistry
|August 27, 2013
PubMed
Summary
This summary is machine-generated.

Autophagy, a cellular recycling process, plays a dual role in cancer. It can suppress tumors by maintaining genome stability or promote cancer growth by providing metabolic support and maintaining cancer stem cells.

Keywords:
AutophagyBNIP3CancerCancer stem cellsMitophagyTherapy resistance

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Cell-Based Drug Screening for Inhibitors of Autophagy Related 4B Cysteine Peptidase
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Last Updated: May 8, 2026

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Assessing Autophagic Flux by Measuring LC3, p62, and LAMP1 Co-localization Using Multispectral Imaging Flow Cytometry
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Area of Science:

  • Cellular Biology
  • Oncology
  • Molecular Biology

Background:

  • Autophagy is a conserved cellular process for degrading and recycling cellular components.
  • It is activated by various physiological and pathological stimuli.
  • Autophagy's role in cancer is complex and context-dependent.

Purpose of the Study:

  • To explore the multifaceted role of autophagy in cancer pathogenesis.
  • To understand how autophagy can act as both a tumor suppressor and a tumor promoter.

Main Methods:

  • Literature review and analysis of existing research on autophagy and cancer.
  • Examination of molecular mechanisms underlying autophagy's dual role.

Main Results:

  • Autophagy can suppress tumors by promoting genome stability, senescence, and autophagic cell death.
  • Conversely, autophagy can support tumor growth by providing metabolic substrates, reducing oxidative stress, and sustaining cancer stem cells.

Conclusions:

  • The role of autophagy in cancer is specific to cancer type and stage.
  • Substrate selectivity in autophagy may determine its specific effect in cancer, representing a key area for future research.