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Updated: May 8, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Improved late survival with arterial revascularization.

Chaim Locker¹, Hartzell V Schaff, Joseph A Dearani

¹Division of Cardiovascular Surgery, Mayo Clinic, Rochester, Minnesota, USA.

Annals of Cardiothoracic Surgery

|August 27, 2013

Summary

Using multiple arterial grafts in coronary artery bypass grafting (CABG) surgery, specifically the left internal mammary artery (LIMA) combined with other arterial grafts, significantly improves long-term survival in patients with multivessel coronary artery disease.

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Area of Science:

Cardiovascular Surgery
Cardiac Surgery Outcomes
Arterial Grafting

Background:

Coronary artery bypass grafting (CABG) remains a cornerstone treatment for multivessel coronary artery disease.
The use of arterial conduits, particularly the left internal mammary artery (LIMA) for the left anterior descending (LAD) coronary artery, is associated with superior long-term outcomes.
The benefit of using additional arterial grafts beyond LIMA for non-LAD targets has been a subject of ongoing debate.

Purpose of the Study:

To investigate the long-term survival impact of using multiple arterial grafts compared to conventional grafting in patients undergoing primary isolated CABG for multivessel disease.
To evaluate whether utilizing additional arterial conduits (right internal mammary artery and/or radial artery) alongside LIMA to the LAD improves survival.

Main Methods:

Keywords:

Internal mammary artery radial artery revascularization saphenous vein grafts

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Last Updated: May 8, 2026

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Reduced Complications after Arterial Reconnection in a Rat Model of Orthotopic Liver Transplantation

Published on: November 7, 2020

Retrospective analysis of a large cohort of 8,622 patients who underwent primary isolated CABG.
Long-term follow-up exceeding 15 years to assess survival rates.
Propensity-matched analysis (1,153 patients per group) and multivariate analysis to control for confounding factors and confirm findings.

Main Results:

The use of at least one additional arterial graft (right internal mammary artery and/or radial artery) to bypass non-LAD targets, in addition to LIMA to the LAD, was an independent predictor of increased survival.
This survival advantage was consistently observed in both propensity-matched and multivariate analyses.
Patients receiving multiple arterial grafts demonstrated a significant survival benefit over 15 years.

Conclusions:

Multiple arterial grafting strategies, utilizing LIMA to the LAD and at least one additional arterial graft, significantly enhance long-term survival in patients with multivessel coronary artery disease.
These findings underscore the importance of considering comprehensive arterial revascularization in CABG surgery.
The survival advantage of multiple arterial grafting should be a key consideration in evolving coronary revascularization strategies.