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Related Concept Videos

Endospores and Sporulation01:20

Endospores and Sporulation

Endospores are specialized, dormant cells primarily formed by Gram-positive bacteria, including Bacillus and Clostridium, enabling survival under extreme environmental conditions. Due to their unique composition and formation process, these structures are highly resistant to physical and chemical insults, such as extreme heat, ultraviolet and ionizing radiation, desiccation, and toxic chemicals. Rare instances of endospore-like structures have also been observed in some Gram-negative bacteria,...

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Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
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Published on: December 8, 2023

Flaxseed and endotoxic shock.

Kailash Prasad1

  • 1Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, Canada, S7N 5E5. k.prasad@usask.ca.

Current Pharmaceutical Design
|August 28, 2013
PubMed
Summary
This summary is machine-generated.

Reactive oxygen species (ROS) contribute to endotoxic shock. Flaxseed, rich in antioxidants, effectively mitigates cardiovascular dysfunction and tissue damage caused by endotoxic shock, suggesting a therapeutic role.

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Area of Science:

  • Cardiovascular Physiology
  • Biochemistry
  • Pharmacology

Background:

  • Endotoxic shock severely impairs cardiovascular function, including cardiac output and contractility.
  • This condition is characterized by oxidative stress, evidenced by increased reactive oxygen species (ROS) and malondialdehyde (MDA) levels, and decreased antioxidant capacity.
  • Cellular damage is indicated by elevated plasma creatine kinase and lactate.

Purpose of the Study:

  • To review the role of ROS in endotoxic shock pathophysiology.
  • To evaluate the efficacy of flaxseed in ameliorating endotoxic shock-induced cardiovascular and cellular damage.

Main Methods:

  • Review of existing literature on endotoxic shock, ROS, and antioxidant interventions.
  • Analysis of studies using antioxidants like dimethylthiourea to counteract endotoxic shock effects.
  • Examination of research on flaxseed's impact on cardiovascular parameters and oxidative stress markers.

Main Results:

  • Endotoxic shock significantly reduces cardiac function, arterial pressure, and cellular health while increasing ROS generation and lipid peroxidation.
  • Antioxidants, including dimethylthiourea and flaxseed, demonstrated protective effects against these detrimental changes.
  • Flaxseed ameliorated endotoxic shock-induced reductions in cardiac function and contractility, and improved arterial pressure and cellular health.

Conclusions:

  • Reactive oxygen species play a significant role in the pathophysiology of endotoxic shock.
  • Flaxseed, owing to its antioxidant properties, shows promise as a therapeutic agent for treating endotoxic shock.