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Updated: May 8, 2026
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Microsporidial keratitis after collagen cross-linking
Gautam1, Vishal Jhanji, Gita Satpathy
1Dr. Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences , New Delhi , India and.
A rare case of Microsporidium infectious keratitis occurred after collagen crosslinking (CXL) for keratoconus. Prompt microbiological diagnosis and medical treatment, including albendazole, led to a favorable visual outcome.
Area of Science:
- Ophthalmology
- Microbiology
Background:
- Collagen crosslinking (CXL) is a standard treatment for progressive keratoconus.
- Infectious keratitis is a potential complication following ocular procedures.
Observation:
- A 36-year-old male developed infectious keratitis with significant vision loss in his left eye six days post-CXL.
- Clinical examination revealed a central epithelial defect and stromal infiltrates.
Findings:
- Corneal scrapings stained with Gram and Giemsa confirmed Microsporidia spores.
- The patient was treated with topical antibiotics, an antifungal agent, and oral albendazole.
- Corneal debridement was performed twice in the first week.
Implications:
- This case highlights Microsporidium as a causative agent of infectious keratitis after CXL.
- Early diagnosis and appropriate medical management, including albendazole, are crucial for successful treatment.
- Microsporidial keratitis following CXL can be effectively managed with medical therapy alone, preserving visual acuity.
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