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Mouse Models of Periventricular Leukomalacia
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Differences between periventricular hemorrhagic infarction and periventricular leukomalacia

Takeshi Tsuji1, Akihisa Okumura2, Hiroyuki Kidokoro3

  • 1Department of Pediatrics, Okazaki City Hospital, Okazaki, Japan.

Brain & Development
|August 28, 2013
PubMed

Insights

Periventricular hemorrhagic infarction (PVHI) in infants is linked to postnatal injury, while periventricular leukomalacia (PVL) is associated with pre- or perinatal injury, differentiating their origins and clinical presentations.

Area of Science:

  • Neonatal Neurology
  • Pediatric Neuroimaging
  • Clinical Neuroscience

Background:

  • Periventricular hemorrhagic infarction (PVHI) and periventricular leukomalacia (PVL) are significant causes of brain injury in preterm infants.
  • Differentiating between PVHI and PVL is crucial for understanding injury mechanisms and prognosis.

Purpose of the Study:

  • To elucidate the distinct clinical, ultrasonographic, and electroencephalographic (EEG) features differentiating infants with PVHI from those with PVL.
  • To investigate the temporal relationship between EEG abnormalities and cranial ultrasonography findings in these two conditions.

Main Methods:

  • Retrospective analysis of clinical data, serial cranial ultrasonography, and electroencephalogram (EEG) in 22 preterm infants with PVHI and 49 with PVL.
  • Evaluation of acute and chronic EEG abnormalities in relation to ultrasonography findings from birth.

Main Results:

  • Infants with PVHI had lower gestational age and birth weight compared to those with PVL.
  • PVHI cases often showed normal EEGs initially, with abnormalities appearing after ultrasonography changes, suggesting postnatal injury.
  • PVL cases more frequently exhibited acute EEG abnormalities early (days 1-2), indicating pre- or perinatal injury.

Conclusions:

  • PVHI is presumed to result primarily from postnatal injury.
  • PVL is presumed to result primarily from pre- or perinatal injury.
  • The timing of EEG abnormalities relative to ultrasonography findings helps distinguish between PVHI and PVL.
Abstract

Keywords:
ElectroencephalographyGestational agePeriventricular hemorrhagic infarctionPeriventricular leukomalaciaTiming of brain injury

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