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Updated: May 8, 2026

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

Respiratory bronchiolitis and lung carcinoma.

Yoshihito Yamada¹, Jiro Terada, Koichiro Tatsumi

¹Department of Chest Medicine, Japan Railway Tokyo General Hospital, Japan.

Respiratory Investigation

|August 28, 2013

Summary

Cigarette smoking is linked to lung cancer and interstitial lung disease. Fibrosis in respiratory bronchiolitis (RB) may increase the risk of squamous cell carcinoma in smokers.

Keywords:

Bronchiolocentric fibrosis Respiratory bronchiolitis Smoking Smoking-related interstitial fibrosis Squamous cell carcinoma

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Last Updated: May 8, 2026

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

Published on: May 26, 2023

Area of Science:

Pulmonary Medicine
Oncology
Pathology

Background:

Cigarette smoking is a primary cause of lung carcinoma and respiratory bronchiolitis (RB), including RB-associated interstitial lung disease (RB-ILD).
The precise relationship between lung cancer and RB/RB-ILD remains unclear.
This study investigated the co-occurrence of pathological fibrosis in lung carcinoma patients, hypothesizing that these fibrous lesions could be precancerous.

Purpose of the Study:

To determine if pathological fibrosis lesions are present in lung carcinoma patients.
To explore the association between respiratory bronchiolitis with fibrosis and specific lung cancer subtypes.
To assess the potential role of smoking-induced interstitial fibrosis in lung cancer development.

Main Methods:

Evaluated clinical, radiological (high-resolution computed tomography - HRCT), and pathological features in 124 lung carcinoma patients (67 current smokers, 22 ex-smokers, 35 nonsmokers).
Pathological examination focused on identifying RB, RB with fibrosis, and coexistent interstitial changes.
Correlated HRCT findings with pathological diagnoses and smoking history (Brinkman index).

Main Results:

RB with fibrosis was found in 13/67 current smokers, often associated with emphysema or specific HRCT patterns.
RB without fibrosis was observed in 12/67 current smokers.
Patients with RB and fibrosis had a significantly higher Brinkman smoking index and were more likely to have squamous cell carcinoma, while those with RB without fibrosis were more likely to have adenocarcinoma.

Conclusions:

Squamous cell carcinoma, particularly in peripheral areas, was primarily associated with RB with fibrosis in heavy smokers.
Adenocarcinoma was more commonly observed in patients with RB without fibrosis.
Continuous heavy cigarette smoking leading to interstitial fibrosis with RB may elevate the risk of developing squamous cell carcinoma.