Post-varicella Guillain Barre syndrome.

Area of Science:

• Neurology
• Virology
• Immunology

Background:

• Guillain Barre Syndrome (GBS) is an autoimmune disorder affecting peripheral nerves.
• Varicella-zoster virus (VZV) is a common human herpesvirus, typically causing chickenpox and shingles.
• A direct link between VZV infection and GBS development is infrequently reported.

Purpose of the Study:

• To investigate the potential association between Varicella-zoster virus (VZV) infection and the onset of Guillain Barre Syndrome (GBS).
• To highlight the significance of a potential VZV role in GBS etiopathogenesis.

Main Methods:

• Case report methodology.
• Clinical observation and temporal relationship analysis between VZV infection and GBS onset.

Main Results:

• Two distinct cases demonstrating a close temporal association between VZV infection (varicella) and the subsequent development of GBS.
• The findings support a potential, albeit rare, role for VZV in triggering GBS.

Conclusions:

• The presented cases suggest Varicella-zoster virus infection should be considered as a potential trigger for Guillain Barre Syndrome.
• Further research is warranted to elucidate the precise mechanisms underlying the VZV-GBS association.